Research
Günter Mayer, Dr. rer. nat.Professor of Chemical Biology and Chemical Geneticsphone: +49 (0)2 28 / 73 - 48 08 |
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| 1992- 1997 | Chemistry studies at the Ludwig-Maximilians-University Munich |
| 1997- 1998 | Diploma thesis at the Ludwig-Maximilians-University Munich, Institute for Biochemistry (Genzentrum). |
| 1998-2001 | PhD thesis at the Ludwig-Maximilians-University Munich, Institute for
Biochemistry (Genzentrum) and at the Rheinische Friedrich-Wilhelms University Bonn, Kekulé-Institute for Organic Chemistry and Biochemistry. |
| 2001-2003 | Head of the Department for Combinatorial Biotechnologies at NascaCell GmbH, Tutzing. |
| 2003-2004 | Co-founder and Head of the Departments for Combinatorial Biotechnologies and Functional Biology of NascaCell Technologies AG, Munich. |
| 2004-2009 | Groupleader (C1) at the Rheinische Friedrich-Wilhelms University Bonn. |
| 05/2009 | Venia Legendi for Chemical Biology and Molecular Biomedicine. |
| 2009-2010 | Reader for Translational Biology at the University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, UK. (Funded by Scottish Universities Life Science Association - SULSA) |
| Since 2010 | Professor for Chemical Biology/Chemical Genetics, Rheinische Friedrich-Wilhelms University Bonn, LIMES Institute. |
Research Interests
- non-coding RNA: riboswitch and micro RNA function
- control of aptamer activity/ caged aptamers
- multifunctional molecules/assembly of polyvalent nucleic acids
- targeting approaches with nucleic acids
- aptamers as antidotes
Key publications
Buff MC, Schäfer F, Wulffen B, Müller J, Pötzsch B, Heckel A, and Mayer G. Dependence of an aptamer on opposed terminal extension: improvement of light-regulation efficiency. Nucleic Acids Res., 2010, 38, 2111-2118.
Mayer G, Butzen S, Lohberger A, Pofahl M, and Heckel A. From selection to caged aptamers: identification of light-dependent ssDNA aptamers targeting cytohesin. Bioorg. Med. Chem. Lett., 2009, 19, 6561-6564.
Mayer G, Müller J, Mack T, Freitag DF, Höver T, Pötzsch B, and Heckel A. Differential regulation of protein sub-domain activity by caged bivalent ligands. ChemBioChem, 2009, 10, 654-657.
Müller J, Isermann B, Dücker I, Salehi M, Meyer M, Friedrich M, Madhusudhan T, Oldenburg J, Mayer G, and Pötzsch B. An Exosite-specific ssDNA Aptamer Inhibits the Anticoagulant Functions of Activated Protein C and enhances Inhibition by Protein C Inhibitor. Chem. Biol., 2009, 16, 442-451.
Müller J, Freitag D, Mayer G, and Pötzsch B. Anticoagulant characteristics of HD1-22, a bivalent aptamer that specifically inhibits thrombin and prothrombinase. J. Thromb. Haemost. 2008, 6, 2105-2112.
Raddatz MSL, Dolf A, Endl E, Knolle P, Famulok M, and Mayer G. Enrichment of cell-targeting and population-specific aptamers by fluorescent-activated cell sorting. Angew. Chem. Int. Ed., 2008, 47, 5190-5193.
Mayer G, Wulffen B, Huber C, Brockmann J, Flicke B, Neumann L, Hafenbradl D, Klebl BM, Lohse MJ, Krasel C, and Blind M. A RNA molecule that specifically inhibits G-protein coupled receptor kinase 2 in vitro. RNA, 2008, 14, 524-534.
Müller J, Wulffen B, Pötzsch B, and Mayer G. Multi-domain targeting generates a high affinity thrombin-inhibiting bivalent aptamer. ChemBioChem, 2007, 8, 2223-2226.
Heckel A, Buff MC, Raddatz MSL, Müller J, Pötzsch B, and Mayer G. An anticoagulant with light triggered antidote activity. Angew. Chem. Int. Ed., 2006, 45, 6748-6750.
Mayer G, Kröck L, Mikat V, Engeser M, and Heckel A. Light-induced formation of G-quadruplex DNA secondary structures. ChemBioChem, 2005, 6, 1966-1970.
Heckel A and Mayer G. Light-regulated aptamer: An anti-thrombin aptamer with caged thymidine nucleobases. J. Am. Chem. Soc., 2005, 127, 822-23.