Research
Christian Kandt, Dr. rer. nat.Group leader
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| 1993-1999 | Biology studies at the Ruhr-University Bochum, Germany |
| 1998-1999 | Diploma in biology at the Department of Biophysics, Ruhr-University Bochum, Germany. (Advisor: PD Dr. Jürgen Schlitter) |
| 1999-2003 | Ph.D. in biology at the Department of Biophysics, Ruhr-University Bochum, Germany (Advisor: PD Dr. Jürgen Schlitter) |
| 2004-2008 | Postdoctoral fellow, Biocomputing - University of Calgary, Canada. (Advisor: Prof. Dr. D. Peter Tieleman) |
| 2007 | Awardee in the "NRW Rückkehrerprogramm" of the Ministry of Innovation, Science, Research and Technology of the federal state of Nordrhein-Westfalen. |
| since 2008 | Junior Research Group leader in Computational Structural Biology - University of Bonn |
Research Interests
Located at the interface between cell or organelle interior and exterior, membrane proteins are of high biological relevance as key players in fundamental processes such as energy conversion, transport, signal recognition and signal transduction.
In our group we use molecular modeling and computer simulations to study membrane transport and antibiotics resistance. With old antibiotics loosing their efficiency faster than new ones can be developed, a detailed understanding of the molecular basis of bacterial multi-drug resistance is paramount for modern biomedical research. Our current main focus is the AcrAB-TolC system, which serves as the major multi-drug efflux pump in /Salmonella typhimurium/ or /Escherichia coli/.
Key publications
Kandt C, Mátyus E, Tieleman DP (2008): Protein Lipid Interactions from a Molecular Dynamics Simulation Point of View. in "Structure & Dynamics of Membranous Interfaces" John Wiley & Sons, Hoboken, NJ, USA. - in press
Coll EP, Kandt C, Bird D, Samuels AL, Tieleman DP (2007): The Distribution and Conformation of Long-chain Plant Wax Components in a Lipid Bilayer. J Phys Chem B. Aug 2;111(30):8702-4.
Kandt C, Ash WL, Tieleman DP (2007): Setting Up and Running Membrane Protein Simulations. Methods 41(4): 475-488
Sonne J, Kandt C, Peters GH, Hansen FY, Jensen MØ, Tieleman DP (2007): Simulation of the coupling between nucleotide binding and transmembrane domains in the ABC transporter BtuCD. Biophysical Journal 92: 2727-2734
Kandt C, Xu Z, Tieleman DP (2006): Opening and closing motions in the periplasmic vitamin B12 binding protein BtuF. Biochemistry 45(44): 13284-92
Kandt C, Gerwert K, Schlitter J (2005): Water Dynamics Simulation as a Tool for Probing Proton Transfer Pathways in a Heptahelical Membrane Protein. Proteins, Struct.Func.Bioinf. - 2005 Feb 15;58(3):528-537
Kandt C, Schlitter J, Gerwert K. (2004): Dynamics of water molecules in the bacteriorhodopsin trimer in explicit lipid/water environment. Biophys J. 2004 Feb;86(2):705-17.