Research
Michael Hoch, Dr. rer. nat.Professor of Developmental Biologyphone: +49 (0)2 28 / 73 - 6 27 36 |
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| 1983-1989 | Undergraduate education in Biology (Dipl.), University of Heidelberg, Germany |
| 1989-1992 | Doctorate (Dr. rer. nat.) in Developmental Biology, Ludwig-Maximilian University of Munich, Germany |
| 1992-1994 | Postdoctoral fellow at the Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany |
| 1994-1999 | Group leader in the Department of Molecular Developmental Biology, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany |
| 1996 | Habilitation in Developmental Genetics and Cell Biology at the Technical University Braunschweig, Germany |
| since 1999 | Full Professor and Chair of Molecular Developmental Biology, Life & Medical Sciences (LIMES)-Institute, University of Bonn, Germany |
| since 2002 | Managing Director of Life & Medical Sciences (LIMES)-Institute Bonn |
Research Interests
Our projects focus on the role gap junction channel proteins of the Innexin multiprotein family in direct cell-to-cell communication, on Insulin signalling and the regulation of cellular and organismal growth, on lipid metabolism and obesity and on the physiology and the maturation of the Drosophila airways. Via genetic screens we have identified new key regulators which we characterize by using a broad range of methods in genetics, molecular biology, biochemistry, cell biology and immune histochemistry, including confocal laser scanning microscopy and structural analysis by EM. Some of the regulators have single othologs in mice and humans and we are starting to analyse their role in tissue culture and mouse models.
Key publications
Becker, T., Loch, G., Beyer, M., Zinke, I., Aschenbrenner, A.C., Carrera, P., Inhester, T., Schultze, J. and Hoch, M. Foxo-dependent regulation of innate immune homeostasis. Nature 2010, 463: 369-373.
Bauer, R., Völzmann, A., Breiden, B., Schepers, U., Farwanah, H., Eckhardt, F., Sandhoff, K. and Hoch, M. Drosophila schlank links cellular sphingolipid metabolism with hormone-dependent body fat regulation. The EMBO Journal 2009, 28: 3706-3716.Löer, B., Bauer, R., Bornheim, R., Grell, J., Kremmer, E., Kolanus, W. and Hoch, M. A pivotal role of the NHL-domain protein Wech for the integrin-cytoskeleton link. Nature Cell Biology 2008, 10: 422-8.
Behr, M., Wingen, C., Wolf, C., Schuh, R. and Hoch, M. Wurst is essential for airway clearance and respiratory-tube size control. Nature Cell Biology 2007, 9: 847-853.
Fuss, B., Becker, T., Zinke, I. and Hoch, M. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 2006, 444: 945-948.