Research
Michael Famulok, Dr. rer. nat.Professor of Chemical Biologyphone: +49 (0)2 28 / 73 - 17 87 |
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| 1981-1986 | University of Marburg, Germany; Field of study: chemistry
Diploma Thesis in the laboratory of Prof. Gernot Boche |
| 1987-1989 | University of Marburg, Germany: PhD Thesis in the laboratory of Prof. Gernot Boche |
| 1989-1990 | Massachusetts Institute of Technology, Cambridge, USA: Postdoctoral in the laboratory of Professor Julius Rebek, Jr. |
| 1990-1992 | Massachusetts General Hospital /Harvard Department of Genetics, Boston, USA: Postdoctoral in the laboratory of Professor Jack W. Szostak |
| 1992-1996 | Inst. für Biochemie - Genzentrum der LMU München, Germany Wissenschaftlicher Assistent |
| 1996-1999 | Inst. für Biochemie - Genzentrum der LMU München, Germany Substitution for a biochemistry professorship |
| since 1999 | Full Professor and Chair of Biochemistry/Bioorganic Chemistry, Life & Medical Sciences (LIMES)-Institute, University of Bonn, Germany |
Research Interests
The central focus of our research lies in the areas of aptamer- and in vitro selection technologies, chemical genetics, and chemical biology. We currently concentrate on the following topics:
- Chemical Genetics: Aptamer-displacement assays for screening of small molecules inhibitors of target proteins
- Novel protein-binding and -inhibitory aptamers / intracellular aptamers („Intramers“)
- Novel catalytic nucleic acids
- Synthetic Aptamers as Biosensors, Diagnostics, and Therapeutics
Key publications
J.S. Hartig, S. H. Najafi-Shoushtari, I. Grüne, A. Yan, A. D. Ellington, M. Famulok Protein-dependent ribozymes report molecular interactions in real-time. Nat. Biotechnol. 2002, 20, 717-722
S. Jäger, G. Rasched, H. Kornreich-Leshem, M. Engeser, O. Thum, M. Famulok A versatile toolbox for variable DNA functionalization at high density. J. Am. Chem. Soc., 2005, 127, 15071-15082.
M. Hafner, A. Schmitz, I. Grüne, S. G. Srivatsan, B. Paul, W. Kolanus, T. Quast, E. Kremmer, I. Bauer, M. Famulok Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance. Nature, 2006, 444, 941-944.
S. Yamazaki, L. Tan, G. Mayer, J.S. Hartig, J.-N. Song, S. Reuter, T. Restle, S. D. Laufer, D. Grohmann, H.-G. Kräusslich, J. Bajorath, M. Famulok Aptamer displacement identifies alternative small-molecule target sites that escape viral resistance Chem. Biol. 2007, 14, 804-812.
G. Rasched, D. Ackermann, T. L. Schmidt, P.Broekmann, A. Heckel, M. Famulok DNA minicircles with gaps for versatile functionalization. Angew. Chem. Int. Ed. 2008, 47, 967-970.
M.-S. Raddatz, E. Endl, Dolf, P. Knolle, M. Famulok, G. Mayer Fluorescent-activated cell sorting enriches cell-targeting and population-specific aptamers. Angew. Chem. Int. Ed. 2008, 47, 5190-5193.
X. Bi, A. Schmitz, A. M. Hayallah, J.-N. Song, M. Famulok Affinity-based labeling of cytohesins with a bifunctional ecinH3 photoaffinity probe.
Angew. Chem. Int. Ed. Engl. 2008, 47, 9565-9568.