Research
Sven Burgdorf , Dr. rer. nat.Professor of Cellular Immunologyphone: +49 (0)2 28 / 73 - 6 28 25 |
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| 1993-1998 | Master in Bio-Engineering for Cell and Gene Biotechnology, University of Leuven, Belgium |
| 1998 | Diploma thesis at the German Cancer Research Center in Heidelberg |
| 1998-1999 | Research fellow at the Max Planck Institute for plant breeding research, Cologne |
| 1999-2000 | Research fellow at MPB Cologne GmbH |
| 2000-2003 | PhD thesis at the Institute of Genetics, University of Bonn (Prof. K. H. Scheidtmann) |
| 2004-2008 | Post-doc fellow at the Institute of Molecular Medicine and Experimental Immunology, University of Bonn (Prof. C. Kurts) |
| 2008-2010 | Independent research group leader at the Institute of Molecular Medicine, University of Bonn |
| Since 2010 | Professor of Cellular Immunology at the LIMES Institute |
Research Interests
We are interested in the molecular mechanisms governing antigen presentation and T cell activation. We investigate antigen uptake, intracellular routing, processing and loading onto MHC molecules by dendritic cells. Of main interest is the influence of endocytosis mechanisms on these processes. Additionally, we investigate the role of endocytic receptors as regulators of T cell activity.
Key publications
Burgdorf, S., Schuette, V., Semmling, V., Hochheiser, K., Lukacs-Kornek, V., Knolle, P.A. and Kurts, C. (2010) Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments Proc Natl Acad Sci USA 107(13):E48-9.
Klotz, L., Hucke, S., Thimm, D., Classen, S., Gaarz, A., Schultze, J., Edenhofer, F., Kurts, C., Klockgether, T., Limmer, A., Knolle, P. and Burgdorf, S. (2009) Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1. J Immunol. 183(1):129-36.
Burgdorf, S., Schölz, C., Kautz, A., Tampé, R. and Kurts, C. (2008) Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation. Nature Immunol, 9(5): 558-566.
Burgdorf, S., Kautz, A., Böhnert, V., Knolle, P.A. and Kurts C. (2007). Distinct antigen uptake and intracellular routing mechanisms for CD4 or CD8 T cell activation. Science, 316(5824): 612-6.
Burgdorf, S., Lukacs-Kornek, V. and Kurts, C. (2006). The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation. J Immunol 176(11), 6770-6.