Research
Susanne Buch, Dr. rer. nat.Group leader
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| 1996-2002 | Biology studies (Diploma), University of Karlsruhe |
| 2003-2006 | Dissertation, Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe (Karlsruhe Institute of Technology, KIT) |
| 2006-2008 | Postdoctoral fellow, Institute of Toxicology and Genetics, Forschungszentrum Karlsruhe (Karlsruhe Institute of Technology, KIT) |
| 2008-2010 | Postdoctoral fellow, Life & Medical Sciences (LIMES)-Institute, University of Bonn |
| since 2010 | Independent junior research group leader, Life & Medical Sciences Institute (LIMES), University of Bonn |
Research Interests
The rapid rise of nutrient related metabolic diseases points out the necessity to understand the mechanisms involved. Nutrition influences metabolism in various aspects, such as nutrient storage, reproduction, growth, longevity and health.
To investigate nutrient related changes of gene expression, we use the model organism Drosophila melanogaster which can be manipulated very easily and precisely. In this context, we are asking how, in addition to sugar, amino acids affect insulin signaling. Furthermore, we are investigating the impact of gender in this issue, as the different sexes have varying needs according to feeding, reproduction and immune defense.
Key publications
Buch S, Pankratz MJ., Making metabolic decisions in Drosophila, Fly (Austin). 2009 Jan-Mar;3(1):74-7.
Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz MJ., Opposing effects of dietary protein and sugar regulate a target of Drosophila insulin-like peptide signaling, Cell Metab. 2008 Apr;7(4):321-32.
Min KJ, Yamamoto R, Buch S, Pankratz M, Tatar M., Drosophila lifespan control by dietary restriction independent of insulin-like signaling,
Aging Cell. 2008 Mar;7(2):199-206.