Selected publications

 

 

 

 

Wähe A, Kasmapour B, Schmaderer C, Liebl D, Sandhoff K, Nykjaer A, Griffiths G, Gutierrez MG. Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin.
J Cell Sci. 2010 Jul 15;123(Pt 14):2502-11.

Bajorath J, Stumpfe D, Bill A, Novak N, Loch G, Blockus H, Geppert HC, Becker T, Hoch M, Famulok M, Kolanus W, Schmitz A. Targeting multi-functional proteins by virtual screening: structurally diverse cytohesin inhibitors with differentiated biological functions.
ACS Chem Biol. 2010 Jul 8. [Epub ahead of print]

Burgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C. Taking off the brakes: T cell immunity in the liver.
Trends Immunol. 2010 Jul 7. [Epub ahead of print]

Abdul-Hammed M, Breiden B, Adebayo MA, Babalola JO, Schwarzmann G, Sandhoff K. Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.
J Lipid Res. 2010 Jul;51(7):1747-60.

Ahmed MS, Mayer G. Evolution of specific RNA motifs derived from pan-protein interacting precursors.
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3793-6.

Lünse CE, Michlewski G, Hopp CS, Rentmeister A, Cáceres JF, Famulok M, Mayer G. An Aptamer Targeting the Apical-Loop Domain Modulates pri-miRNA Processing.
Angew Chem Int Ed Engl. 2010 Jun 8.

Ackermann D, Schmidt TL, Hannam JS, Purohit CS, Heckel A, Famulok M. A double-stranded DNA rotaxane.
Nat Nanotechnol. 2010 Jun;5(6):436-42.

Gaarz A, Debey-Pascher S, Classen S, Eggle D, Gathof B, Chen J, Fan JB, Voss T, Schultze JL, Staratschek-Jox A. Bead array-based microrna expression profiling of peripheral blood and the impact of different RNA isolation approaches.
J Mol Diagn. 2010 May;12(3):335-44. Epub 2010 Mar 12.

Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H, Förster I. Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells.
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8736-41. Epub 2010 Apr 26.

Kolter T, Sandhoff K. Lysosomal degradation of membrane lipids.
FEBS Lett. 2010 May 3;584(9):1700-12. Epub 2009 Oct 16. Review.

Buff MC, Schäfer F, Wulffen B, Müller J, Pötzsch B, Heckel A, Mayer G. Dependence of aptamer activity on opposed terminal extensions: improvement of light-regulation efficiency.
Nucleic Acids Res. 2010 Apr;38(6):2111-8.

Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C. Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs.
Nat Immunol. 2010 Apr;11(4):313-20. Epub 2010 Feb 28.

Burgdorf S, Schuette V, Semmling V, Hochheiser K, Lukacs-Kornek V, Knolle PA, Kurts C. Steady-state cross-presentation of OVA is mannose receptor-dependent but inhibitable by collagen fragments.
Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):E48-9; author reply E50-1. Epub 2010 Mar 22.

Classen S, Muth C, Debey-Pascher S, Eggle D, Beyer M, Mallmann MR, Rudlowski C, Zander T, Pölcher M, Kuhn W, Lahn M, Schultze JL, Staratschek-Jox A. Application of T cell-based transcriptomics to identify three candidate biomarkers for monitoring anti-TGFbetaR therapy.
Pharmacogenet Genomics. 2010 Mar;20(3):147-56.

Shina MC, Müller R, Blau-Wasser R, Glöckner G, Schleicher M, Eichinger L, Noegel AA, Kolanus W. A cytohesin homolog in Dictyostelium amoebae.
PLoS One. 2010 Feb 23;5(2):e9378.

Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, Kinnunen PK, Nylandsted J, Jäättelä M. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology.
Nature. 2010 Jan 28;463(7280):549-53.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J. Chaperone-assisted selective autophagy is essential for muscle maintenance.
Curr Biol. 2010 Jan 26;20(2):143-8. Epub 2010 Jan 7.

Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner AC, Carrera P, Inhester T, Schultze JL, Hoch M. FOXO-dependent regulation of innate immune homeostasis.
Nature. 2010 Jan 21;463(7279):369-73.

Bauer R, Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch M. Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila.
EMBO J. 2009 Dec 2;28(23):3706-16.

Mayer G, Lohberger A, Butzen S, Pofahl M, Blind M, Heckel A. From selection to caged aptamers: identification of light-dependent ssDNA aptamers targeting cytohesin.
Bioorg Med Chem Lett. 2009 Dec 1;19(23):6561-4.

Imgrund S, Hartmann D, Farwanah H, Eckhardt M, Sandhoff R, Degen J, Gieselmann V, Sandhoff K, Willecke K. Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas.
J Biol Chem. 2009 Nov 27;284(48):33549-60. Epub 2009 Sep 30.

Famulok M. Exploring chemical space with aptamers.
J Med Chem. 2009 Nov 26;52(22):6951-7. No abstract available.

Jones CA, Nishiya N, London NR, Zhu W, Sorensen LK, Chan AC, Lim CJ, Chen H, Zhang Q, Schultz PG, Hayallah AM, Thomas KR, Famulok M, Zhang K, Ginsberg MH, Li DY. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity.
Nat Cell Biol. 2009 Nov;11(11):1325-31.

Mayer G. Tiny tags on RNA.
Chembiochem. 2009 Sep 4;10(13):2145-6.

Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA. The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
J Exp Med. 2009 Sep 28;206(10):2079-89.

von Maltzahn J, Kreuzberg MM, Matern G, Euwens C, Höher T, Wörsdörfer P, Willecke K. C-terminal tagging with eGFP yields new insights into expression of connexin45 but prevents rescue of embryonic lethal connexin45-deficient mice.
Eur J Cell Biol. 2009 Sep;88(9):481-94.

Dobrowolski R, Hertig G, Lechner H, Wörsdörfer P, Wulf V, Dicke N, Eckert D, Bauer R, Schorle H, Willecke K. Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice.
Hum Mol Genet. 2009 Aug 1;18(15):2899-911.

Klotz L, Hucke S, Thimm D, Classen S, Gaarz A, Schultze J, Edenhofer F, Kurts C, Klockgether T, Limmer A, Knolle P, Burgdorf S. Increased antigen cross-presentation but impaired cross-priming after activation of peroxisome proliferator-activated receptor gamma is mediated by up-regulation of B7H1.
J Immunol. 2009 Jul 1;183(1):129-36. Epub 2009 Jun 17.

Eggle D, Debey-Pascher S, Beyer M, Schultze JL. The development of a comparison approach for Illumina bead chips unravels unexpected challenges applying newest generation microarrays.
BMC Bioinformatics. 2009 Jun 18;10:186.

Quast T, Tappertzhofen B, Schild C, Grell J, Czeloth N, Förster R, Alon R, Fraemohs L, Dreck K, Weber C, Lämmermann T, Sixt M, Kolanus W. Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells.
Blood. 2009 Jun 4;113(23):5801-10.

Beyer M, Karbach J, Mallmann MR, Zander T, Eggle D, Classen S, Debey-Pascher S, Famulok M, Jäger E, Schultze JL. Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy".
Cancer Res. 2009 May 15;69(10):4346-54.

Mayer G, Famulok M. In vitro selection of conformational probes for riboswitches.
Methods Mol Biol. 2009;540:291-300.

Schrickel JW, Kreuzberg MM, Ghanem A, Kim JS, Linhart M, Andrié R, Tiemann K, Nickenig G, Lewalter T, Willecke K. Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice.
J Mol Cell Cardiol. 2009 May;46(5):644-52.

Beyer M, Karbach J, Mallmann MR, Zander T, Eggle D, Classen S, Debey-Pascher S, Famulok M, Jäger E, Schultze JL. Cancer vaccine enhanced, non-tumor-reactive CD8(+) T cells exhibit a distinct molecular program associated with "division arrest anergy".
Cancer Res. 2009 May 15;69(10):4346-54. Epub 2009 May 12.

Matzner U, Breiden B, Schwarzmann G, Yaghootfam A, Fluharty AL, Hasilik A, Sandhoff K, Gieselmann V. Saposin B-dependent reconstitution of arylsulfatase A activity in vitro and in cell culture models of metachromatic leukodystrophy.
J Biol Chem. 2009 Apr 3;284(14):9372-81.

Staratschek-Jox A, Classen S, Gaarz A, Debey-Pascher S, Schultze JL. Blood-based transcriptomics: leukemias and beyond.
Expert Rev Mol Diagn. 2009 Apr;9(3):271-80. Review.

Buch S, Pankratz MJ. Making metabolic decisions in Drosophila.
Fly (Austin). 2009 Jan-Mar;3(1):74-7. Epub 2009 Jan 8. Review.

Beyer M, Schultze JL. Regulatory T cells: major players in the tumor microenvironment.
Curr Pharm Des. 2009;15(16):1879-92. Review.

Eggeling C, Ringemann C, Medda R, Schwarzmann G, Sandhoff K, Polyakova S, Belov VN, Hein B, von Middendorff C, Schönle A, Hell SW. Direct observation of the nanoscale dynamics of membrane lipids in a living cell.
Nature 2009, 457:1159-62.

Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz MJ. Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling.
Cell Metabolism 2008, 7:321-32. (Comment in Cell Metab. 2008 7:281-3).

Rouach N, Koulakoff A, Abudara V, Willecke K, Giaume C. Astroglial metabolic networks sustain hippocampal synaptic transmission.
Science 2008, 322:1551-5.

Raddatz MS, Dolf A, Endl E, Knolle P, Famulok M, Mayer G. Enrichment of cell-targeting and population-specific aptamers by fluorescence-activated cell sorting.
Angew Chem Int Ed Engl. 2008, 47:5190-3.

Burgdorf S, Schölz C, Kautz A, Tampé R, Kurts C. Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation.
Nat Immunol. 2008 May;9(5):558-66.

Burgdorf S, Kurts C. Endocytosis mechanisms and the cell biology of antigen presentation.
Curr Opin Immunol. 2008 Feb;20(1):89-95. Epub 2008 Jan 30. Review.

Hafner M, Vianini E, Albertoni B, Marchetti L, Grüne I, Gloeckner Ch and Famulok M. Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization.
Nat Protocols 2008, Vol. 3 No. 4:579-587.

Löer B, Bauer R, Bornheim R, Grell J, Kremmer E, Kolanus W, Hoch M. The NHL-domain protein Wech is crucial for the integrin-cytoskeleton link.
Nat Cell Biol. 2008, 10: 422-8.

Min KJ, Yamamoto R, Buch S, Pankratz M, Tatar M. Drosophila lifespan control by dietary restriction independent of insulin-like signaling.
Aging Cell 2008, 7:199-206.

Mayer G, Ackermann D, Kuhn N, Famulok M.  Construction of DNA Architectures with RNA Hairpins. 
Angew Chem Int Ed Engl. 2008, 47: 971-973.

Rasched G, Ackermann D, Schmidt TL, Broekmann P, Heckel A, Famulok M. DNA Minicircles with Gaps for Versatile Functionalization.
Angew Chem Int Ed Engl. 2008, 47:967-970.

Wawer M, Peltason L, Weskamp N, Teckentrup A & Bajorath J. Structure-activity relationship anatomy by network-like similarity graphs and local structure-activity relationship indices.
J Med Chem 2008, 51: 6075-6084.

Roell W, Lewalter T, Sasse P, Tallini YN, Choi BR, Breitbach M, Doran R, Becher UM, Hwang SM, Bostani T, von Maltzahn J, Hofmann A, Reining S, Eiberger B, Gabris B, Pfeifer A, Welz A, Willecke K, Salama G, Schrickel JW, Kotlikoff MI, Fleischmann BK. Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.
Nature 2007, 450:819-24.

Behr, M., Wingen, C., Wolf, C., Schuh, R. and Hoch, M. Wurst is essential for airway clearance and respiratory-tube size control.
Nat Cell Biol. 2007, 9:847-53.

Burgdorf S, Kautz A, Böhnert V, Knolle PA, Kurts C. Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation.
Science. 2007 Apr 27;316(5824):612-6.

Sieber, J.J., Willig, K. I., Kutzner, C., Gerding-Reimers, C., Harke, B., Donnert, G., Rammner, B., Eggeling, C., Hell, S. W., Grubmüller, H., Lang, T. Anatomy and dynamics of a supramolecular membrane protein cluster.
Science 2007, 317:1072-1076.

Gareus R, Huth M, Breiden B, Nenci A, Rösch N, Haase I, Bloch W, Sandhoff K, Pasparakis M. Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation.
Nat Cell Biol. 2007, 9:461-9.

Peltason L., Bajorath J.  Correlation of similarity and potency of enzyme inhibitors unvovers the presence of heterogenous structure-activity relationships and variable activity landscapes within active sites.
Chem. Biol. 2007, 14:489-97.

Hafner M., Schmitz A., Grüne I., Srivatsan S. G., Paul B., Kolanus W., Quast T., Kremmer E., Bauer I., Famulok M. Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance.
Nature 2006, 444, 941-944. (News & Views in Nature 2006, 444, 833)

Fuss B., Becker T., Zinke I., Hoch M. The cytohesin Steppke is essential for insulin signalling in Drosophila.
Nature 2006, 444, 945-948. (News & Views in Nature 2006, 444, 833)

Melcher C, Bader R, Walther S, Simakov O, Pankratz MJ. Neuromedin U and its putative Drosophila homolog hugin.
PLoS Biol. 2006, 4:e68.

Zilly, F.E., Sørensen, J.B., Jahn, R. and Lang, T. Munc18-bound syntaxin readily forms SNARE complexes with synaptobrevin in native plasma membranes.
PLoS Biol. 2006, 4:1789-1797.

Popov A, Abdullah Z, Wickenhauser C, Saric T, Driesen J, Hanisch F. G., Domann E, Raven E, Dehus O, Hermann C, Eggle D, Debey S, Chakraborty T, Krönke M, Utermöhlen O, Schultze JL. Containment of pathogens in granulomatous infection - new role of dendritic cells revealed in human listeriosis.
J Clin Invest 2006, 116:3160-70.

Bukauskas FF, Kreuzberg MM, Rackauskas M, Bukauskiene A, Bennett MV, Verselis VK, Willecke K. Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart.
Proc Natl Acad Sci U S A. 2006, 103:9726-31.

Kreuzberg MM, Schrickel JW, Ghanem A, Kim JS, Degen J, Janssen-Bienhold U, Lewalter T, Tiemann K, Willecke K. Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node.
Proc Natl Acad Sci U S A. 2006, 103:5959-64.

Melcher C, Bader R., Walther S, Simakov O., Pankratz M. J.   Candidate gustatory interneurons modulating feeding behavior in the Drosophila brain.
PLoS Biol. 2005, 3, 1618-1629.

Shamri R., Grabovsky V., Gauguet J.M., Feigelson S., Manevich E., Kolanus W., Robinson M.K., Staunton D.E., von Andrian U.H., Alon R. Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines. 
Nat. Immunol. 2005, 6, 497-506. (News & Views in Nat. Immunol. 2005, 6, 429).

Panáková D, Sprong H, Marois E, Thiele C, Eaton S. Lipoprotein particles are required for Hedgehog and Wingless signalling.
Nature 2005, 435:58-65. Comment in: Nature 2005, 435:30-3.

Söhl G, Maxeiner S, Willecke K. Expression and functions of neuronal gap junctions.
Nat Rev Neurosci. 2005, 6:191-200.

Theis, M. G., Knorre, A., Kellersch, B., Moelleken, J., Wieland, F., Kolanus, W., Famulok, M. Discriminatory aptamer reveals serum response element transcription regulated by cytohesin 2.
Proc. Natl. Acad. Sci. USA 2004, 101, 11221-11226

Witte V, Laffert B, Rosorius O, Lischka P, Blume K, Galler G, Stilper A, Willbold D, D'Aloja P, Sixt M, Kolanus J, Ott M, Kolanus W, Schuler G, Baur ASHIV-1 Nef mimics an integrin receptor signal that recruits the polycomb group protein Eed to the plasma membrane.
Mol Cell 2004, 13, 179-190.

Boehm T, Hofer S, Winklehner P, Kellersch B, Geiger C, Trockenbacher A, Neyer S, Fiegl H, Ebner S, Ivarsson L, Schneider R, Kremmer E, Heufler C, Kolanus W. Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.
EMBO J. 2003, 22, 1014-1024.

Hartig, J.S., Najafi H., Grüne I., Yan A., Ellington A. D., Famulok M. Protein-dependent ribozymes report molecular interactions in real-time.
Nat. Biotechnol. 2002, 20, 717-722.

Jenne, A., Hartig, J. S., Piganeau, N., Tauer, A., Samarsky, D. A., Green, M. R., Davies, J., Famulok, M. Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology.
Nat. Biotechnol. 2001, 19, 56-61.

Mayer, G., Blind, M., Nagel, W., Böhm, T., Knorr, T., Jackson, C. L., Kolanus, W., Famulok, M. Controlling small guanine-nucleotide exchange factor function through cytoplasmic RNA intramers.
Proc. Natl. Acad. Sci. USA 2001, 98, 4961-4965

Trojan, AH, Schultze JL, Vonderheide RH, Ladetto M, Donovan JW, Gribben JG. CTL Responses against Immunoglobulin: Identification of Rare Unique Epitopes but Multiple Shared Framework Derived Sequences.
Nat Medicine 2000, 6: 667-673.